副教授
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王海龙
发布时间: 2022年01月05日浏览次数:


王海龙 副教授/硕导

学科(方向):生殖生理学

所在系部:基础医学部

办公电话:0592-2880568

邮    箱:hailongwang@giubbottimoncler2011.com


研究领域:

课题组始终围绕人类辅助生殖技术开展系列研究工作,聚焦于卵子发育质量对生育结局的影响,紧密结合临床开展相关课题研究,以实验动物为模型,研究卵母细胞减数分裂和受精的信号转导、不对称分裂纺锤体组装与迁移、染色体分离调节、卵母细胞极性和早期胚胎发育。

本课题组坚持以立德树人为根本,培养具有团队精神的独立科研工作者为己任。研究生进入课题组后,进行生殖医学相关课题研究、发表论文,同时能够掌握临床上的试管婴儿技术,为毕业求职奠定良好的基础;对于想进一步深造的同学来说,M88的受精机制研究是医学与生命科学的开始,理解医学与生命的本质,可为以后深入基础研究打开科学梦想之门。


学习经历:

1996-2000 东北农业大学  动物科学专业   学士;

2000-2003东北农业大学 动物遗传育种与繁殖专业  硕士;      2003-2007 中科院动物所与东北农业大学联培 动物胚胎学  博士。


工作经历:

2007-2013  M88    讲师;

2013-2014  美国西奈山医学院,访问学者;

2013-至今  M88    副教授;


主持过的重要课题:

  1. 国家重点研发计划项目(2017YFD0501905):母畜繁殖调控新兽药研发,2017/07-2020/12

  2. 国家自然科学基金面上项目(31672248):TACC3调节小鼠卵母细胞减数分裂的机制,2017/01-2020/12

  3. 国家自然科学基金青年项目(31201695):糖尿病影响小鼠卵母细胞组蛋白乙酰化的机制,2013/01-2015/12


期刊论文:

  1. He S, Xu B, Liu Y, Wang Y, Chen M, Xu L, Liao B, Lui R, Li F, Lin Y, Fu X, Fu B, Hong Z, Liu Y,  Qi ZQ*, Wang H*.SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes. Cell Cycle. 2017 Sep 21:1-10. doi: 10.1080/15384101. 2017. 1380126. (Corresponding author) *

  2. Liu Y, Wang Y, He S, Chen M, Zhang Z, Fu X, Fu B, Liao B, Lin Y, Qi Z*, Wang H*. Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes.Oncotarget. 2017 Jan 24; 8(4):6233-6245. doi: 10.18632/oncotarget.14056. (Corresponding author) *

  3. Chen M, Liu Y, Wang Y, Liu R, Xu B, Zhang F, Li F, Xu L, Lin Y, He S, Liao B, Fu X, Wang X, Yang X*, Wang H*. KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte. Sci Rep. 2016 Dec 19;6:39337. doi: 10.1038/srep39337 (Corresponding author) *

  4. Liu Y, Xu B, Liu R, Xu L, Zhang F, Li F, Zhang Z, Wang Y, Chen M, Qi Z*, Wang H*, Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation, Mol Reprod Dev.2016 Jul 19. doi: 10.1002/mrd.22683. (Corresponding author) *

  5. He XSong YLiu RLiu YZhang FZhang ZShen YXu LChen MWang YXu BYang X*, Wang H*, Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. PloS One. 2016 Jun 10;11(6):e0157197. (Corresponding author) *

  6. Shen Y, Song Y, He X, Zhang F, Huang X, Liu Y, Ding L, Xu L, Zhu M, Hu W, Qi Z, Wang H*, Yang X*, Triphenyltin chloride induces spindle microtubule deploy-merization and inhibits meiotic maturation in mouse oocytes, Reprod Fertil Dev. 2014 Oct;26(8):1084-93. (Corresponding author) *

  7. Huang X, Ding L, Pan R, Ma P, Cheng P, Zhang C, Sheng Y, He X, Qi Z*, Wang H*,WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Histochem Cell Biol.2013 Apr;139(4):525-34 (Corresponding author) *

  8. Liu Y, Huang X, He X, Ding L, Xu L, Shen Y, Zhang F, Zhu M, Qi Z*, Wang H*, Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage, PloS One. 2013 Oct 23;8(10):e77960 (Corresponding author) *

  9. Ding L, Pan R, Huang X, Wang J, Shen Y, Xu L, Zhang Y, Liu Y, He X, Yang X, Qi Z*, Wang H*,Changes in histone acetylation during oocyte meiotic maturation in diabetic mouse. Theriogenology. 2012 Sep;78(4):784-92. (Corresponding author) *

  10. Huang XTong JWang ZYang CQi SGuo LOuyang YQuan SSun Q, Qi Z, Huang R*, Wang H*, JNK2 participates in spindle assembly during mouse oocyte meiotic maturation. Microsc Microanal. 2011Apr;17(2):197-205.  (Corresponding author) *

  11. Huang X#Wang H# ,Qi SWang ZTong JZhang QOuyang YHou YSchatten H., Qi ZSun Q.  DYNLT3 is required for chromosome alignment during mouse oocyte meiotic maturation. Reprod Sci. 2011 Oct; 18(10): 983-9. (Co-first author)#

  12. Lan TWang LXu LJin NYan GXia JWang H*, Zhuang GGao CMeng LDu FZhou QQi Z, Induced Pluripotent Stem Cells Can Effectively Differentiate into Multiple Functional Lymphocyte Lineages In Vivo with Negligible Bias. Stem Cells Dev. 2016 Mar 15;25(6):462-71.

  13. Ding J, Huang X, Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A, Shliaha PV, Wang H*, Waghray A, Papatsenko D, Sánchez-Priego C, Li D, Yuan Y, Lemischka IR, Shen L, Kelley K, Deng H, Shen X, Wang J. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell. 2015 Jun 4;16(6):653-68. 

  14. Cheng PXia JWang H*, Chen JWang FZhang YHuang XZhang Q,  Qi Z. Islet transplantation reverses the effects of maternal diabetes on mouse oocytes. Reproduction. 2011 Apr;141(4):417-24.


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