副教授
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杨立朝
发布时间: 2022年01月05日浏览次数:

杨立朝  

职称:副教授/硕导

学科(专业):药理学学

研究方向:心脑血管的发病机理及药物筛选

电子邮箱: yanglc116@giubbottimoncler2011.com

电话:0592-2188676


教育背景:

2003-2007山东泰山医学院  药学系  本科

2007-2010厦门大学大学    药理学  硕士

2010-2013北京协和医学院 药理学  博士


工作经历:

2013.10-2013.11厦门大学 博士后(师资)

2015.12-至今   M88 副教授


主要研究领域:

专注于心脑血管病变领域,重点研究PPARα对心脑血管损伤的保护作用及机制,并注重从油酰乙醇胺结构类似物中筛选一批以PPARα为靶点的防治心脑血管病变药物,为进一步转化和开发新药奠定基础。近两年内成功申报并主持了国家自然科学基金青年基金项目一项、福建省自然科学基金一项、厦门市中医院横向项目两项、参与横向项目一项;近3年在国内外刊物上公开发表论文7篇(包括Biochemical Pharmacology、Neuropharmacology、European Journal of Pharmacology,CNS Neuroscience & Therapeutics等国际权威药理学期刊)。



主要学术成果:

论文:

1、Li-chao Yang, Han Guo, Hao Zhou, Da-qin Suo, Wen-jun Li, Yu Zhou, Yun Zhao, Wu-shuang Yang, Xin Jin. Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia. Biochemical Pharmacology 94 (2015) 270–281.

2、San-Gang Wu1, Jia-Yuan Sun1, Li-Chao Yang1, Juan Zhou, Feng-Yan Li, Qun Li, Huan-Xin Lin, Qin Lin, Zhen-Yu He. Prognosis of patients with esophageal squamous cell carcinoma after esophagectomy using the log odds of positive lymph nodes. Oncotarget. 2015 Sep 29 2009 ,27(Jul 10). 2516-2526. 

3、Zhou Y1,Yang L1, Ma A, Zhang X, Li W, Yang W, Chen C, Jin X. Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor α. Neuropharmacology, 63(2):242-9, 2012. 

4、Li-Chao Yang, Jiang Li, Shao-Feng Xu, Jie Cai, Hui Lei, Dong-Mei Liu, Man Zhang, Xian-Fang Rong, Dan-DanCui, Ling Wang, Ying Peng & Xiao-Liang Wang. L-3-n-butylphalide Promotes Neurogenesis and Neuroplasticity After Focal Cerebral Ischemia in Rats. CNS Neuroscience & Therapeutics Volume 21, Issue 9, pages 733–741, September 2015 

5、Cai-Xia Chen1, Li-chao Yang1, Xu-Dong Xu, Xiao Wei, Ya-Ting Gai, Xin Jin. Effect of propane-2-sulfonic acid octadec-9-enyl-amide-2 on the expression of adhesion molecules in human umbilical vein endothelial cells. European Journal of Pharmacology 756 (2015) 15–21.

6、Juan Zhou1, Li-chao Yang1, Zhen-yu He, Fang-yan Li, San-gang Wu and Jia-yuan Sun. Prognostic Impact of ABO Blood Group on the Survival in Patients with Ovarian Cancer. J Cancer. 2015 Aug 8;6(10):970-5.

7、San-Gang Wu1, Jia-Yuan Sun1, Li-Chao Yang1, Juan Zhou, Feng-Yan Li, Qun Li, Huan-Xin Lin, Qin Lin, Zhen-Yu He. Prognosis of patients with esophageal squamous cell carcinoma after esophagectomy using the log odds of positive lymph nodes. Oncotarget, Advance Publications 2016.

8、Yun Zhao, Lu Yan, Xiu-Mei Luo, Lu Peng, Han Guo, Zuo Jing, Li-Chao Yang, Rong Hu, Xuan Wang, Xue-Feng Huang, Yi-Qing Wang, Xin Jin. A novel PPARα agonist propane-2-sulfonic acid octadec-9-enyl-amide inhibits inflammation in THP-1 cells. European Journal of Pharmacology 788 (2016) 104–112.

9、Xu X, Guo H, Jing Z, Yang L, Chen C, Peng L, Wang X, Yan L, Ye R, Jin X, Wang Y. N-Oleoylethanolamine reduces inflammatory cytokines and adhesion molecules in TNF-α-induced human umbilical vein endothelial cells by activating CB2 and PPAR-α. J Cardiovasc Pharmacol. 2016 Jun 7.

主持课题:

1、国家自然科学基金,油酰乙醇胺对缺血性脑卒中神经血管稳态重构的作用与机制研究,2015.01-2017.12

2、福建省自然科学基金,油酰乙醇胺调控小胶质细胞极化状态的作用及与机制研究,2016.04-2019.04

3、横向,油酰乙醇胺调节脑缺血后小胶质细胞激活的作用研究,2015.07-2016.07

4、横向,油酰乙醇胺抑制脑缺血后炎症反应的作用研究,2015.10-2016.10

5、横向,Z-十八碳-9-烯-丙磺胺对脑卒中后神经血管稳态重构的作用在机制研究,2016.07-2017.07




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