副教授
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任杰
发布时间: 2022年01月05日浏览次数:


任 杰教授/

学科(方向):基础医学

所在系部:厦门大学基础医学部

邮    箱:renjie_7912@giubbottimoncler2011.com


学习经历:

1997~2001 吉林大学/沈阳药科大学(联合培养)生物制药系   学士

2001~2006 沈阳药科大学生物制药系                      博士

2003~2003 韩国釜山大学  生物化学专业  交流学习

工作经历

2005~2015  M88,讲师

2015~至今  M88,副教授

2008~2008  美国加州大学尔湾分校,药理学系,访问学者

代表性成果:

1. Yan Qiu†, Jie Ren†, Hongwei Ke, Yang Zhang, Qi Gao, Longhe Yang, Canzhong Lu* and Yuhang Li*, Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors, RSC Advances, 2017, 7, 22699-22705;

2. Jie Ren, Yuhang Li*, Hongwei Ke, Yanting Li, Longhe Yang, Helin Yu, Rui Huang, Canzhong Lu, and Yan Qiu*, Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors, RSC Advances, 2017,7, 12455-12463;

3. Yuhang LiQi ChenLonghe YangYanting LiYang ZhangYan Qiu*, Jie Ren,  Canzhong Lu*, Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives, European Journal of Medicinal Chemistry, 2017, 139, 214-221;

4. Ling Chen, Jie Ren, Longhe Yang, Yanting Li, Jin Fu, Yuhang Li, Yifeng Tian, Funan Qiu, Zuguo Liu*, Yan Qiu*, Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis, Scientific Reports, 2016, 6, 19665; doi: 10.1038/srep19665;

5. Yan Qiu*, Yang Zhang, Yuhang Li, Jie Ren, Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase, Molecules, 2016, 21, 229; doi:10.3390/molecules21020229;

6.Ling Chen, Huixia Chen, Yanting Li, Lei Li, Yan Qiu and Jie Ren*, Endocannabinoid and ceramide levels are altered in patients with colorectal cancer, Oncology Reports, 2015, 34, 447-454

7. Long Li, Lei Li, Ling Chen, Xiaoyu Lin, Yaping Xu, Jie Ren, Jin Fu, Yan Qiu*, Effect of Oleoylethanolamide on Diet-induced Nonalcoholic Fatty Liver in Rats, Journal of Pharmacological Sciences, 2015, 127, 244-250;

8.Ling Chen#, Long Li#, Junde Chen, Lei Li, Zihan Zheng, Jie Ren, Yan Qiu*, Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells, Oncotarget, 2015, 6 (40), 42530-42540

9.Angran Fan#, Xiaofeng Wu#, Huijuan Wu, Long Li, Rui Huang, Yueyong Zhu, Yan Qiu, Jin Fu, Jie Ren*, Chenggang Zhu*, Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidized LDL, Plos One, 2014, 9 (1), e85337

10. Longhe Yang, Yanting Li, Jie Ren, Chenggang Zhu, Jin Fu, Donghai Lin*, Yan Qiu*, Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2, International Journal of Molecular Sciences, 2014, 15, 13637-13648

11.Xiyue Wu#, Lijun Han#, Xiaolin Zhang, Long Li, Changzhen Jiang, Yan Qiu, Rui Huang, Baoying Xie, ZhiXiong Lin, Jie Ren*, Jin Fu*, Alteration of endocannabinoid system in human gliomas, Journal of Neurochemistry, 2012120 (5), 842-849

主持过的重要课题:

1. 抑制SCD1促进神经酰胺聚集诱导肿瘤细胞凋亡的作用及机制,17.3万元,国家自然科学基金项目(81603145),2017.1-2019.12;主持

2. SCD1调控神经酰胺表达在肠癌发生发展中的作用及机制研究,4万,福建省自然科学基金(2017J01146),2017.04-2020.04,主持

3. 内源性大麻素系统调控脑胶质瘤干细胞机制的研究,3万元,福建省自然科学基金(2013J05122),2013.01-2015.12,主持

所有论文列表

http://www.ncbi.nlm.nih.gov/pubmed/?term=xiamen+University+Jie+Ren



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